Structure - Antifungal Activity Relationships of Polyene 1 Antibiotics of the Amphotericin B Group
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چکیده
15 A comprehensive comparative analysis of the structure – antifungal activity relationships 16 for the series of biosynthetically engineered nystatin analogues, their novel semisynthetic 17 derivatives, as well as amphotericin B (AMB) and its semisynthetic derivatives was performed. 18 The data obtained revealed the significant influence of the structure of the C7 – C10 polyol 19 region on the antifungal activity of these polyene antibiotics. Comparison of positions of 20 hydroxyl groups in the antibiotics and in vitro antifungal activity data showed that the most 21 active are the compounds in which hydroxyl groups are in the positions C8 and C9 or C7 and 22 Copyright © 2013, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00270-13 AAC Accepts, published online ahead of print on 28 May 2013 on A uust 9, 2017 by gest httpaac.asm .rg/ D ow nladed fom
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تاریخ انتشار 2013